This patient presented with a sterile corneal melt and leaking Descemetocele presumed to be due to peripheral ulcerative keratitis. Blood tests showed a positive anti-nuclear antibody (ANA) indicating a likely underlying systemic etiology. We chose to close the defect temporarily with cyanoacrylate glue (Super Glue) and then performed a tectonic lamellar graft to restore structural integrity of the cornea in this area and close the hole. Luckily, the melt did not involve the visual axis and her prognosis for vision is good.