TITLE: Endoscopic Sclerotherapy Technique for the Treatment of Dilated Gastrojejunal Anastomosis after Roux-en-Y Gastric Bypass Background: Dilation of the gastrojejunal anastomosis (GJA) has been shown to reverse the restrictive effects of Roux-en-Y gastric bypass (RYGB). This effect can lead to regain of weight after RYGB. Methods: The video will demonstrate our technique for sclerotherapy to treat dilatation of the GJA utilizing endoscopy. The video will include the method for measuring the GJA for diagnosis of dilation. The video will provide instruction regarding our technique of injecting the GJA every 1cm in a circumferential manner with injection of 1mL of 5% sodium morrhuate. Discussion: In one small series, sclerotherapy was shown to narrow the GJA and lead to stabilization of weight or weight loss in 91.6% of patients. Larger studies are needed to show the efficacy of sclerotherapy as a means of definitive treatment of GJA dilatation. Retrospective review and plans for prospective trials regarding the efficacy of sclerotherapy are currently underway at our institution. Abs# 8338GS Authors: M.L. Simonson, MD, N. Fearing, MD, J. S. Scott, MD, R.A. de la Torre, MD